Huang Changzheng, Liu Zhixiang, Lin Nengxing, Tu Yating, Li Jiawen, Zhang Demei
Department of Dermatology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
J Huazhong Univ Sci Technolog Med Sci. 2003;23(2):203-5. doi: 10.1007/BF02859959.
In order to investigate the susceptibility of mixed infection of Ureaplasma Urealyticum (UU) and Mycoplasma Hominis (MH) to 7 kinds of antimicrobial agents and comparison with that of UU infection in NGU patients, the in vitro susceptibility was determined by using microdilution method. The positive results were analyzed. The results showed that the sequence of susceptibility to 7 kinds of antimicrobial agents for both UU infection group and UU-MH mixed infection group was almost the same from the highest susceptibility to the lowest accordingly: Josamycin, Doxycycline, Minocycline, Sparfloxacin, Roxithromycin, Ofloxacin and Azithromycin. The total drug resistance rate for UU-MH mixed infection group (97.67%) was significantly higher than that for UU infection group (44.67%, P < 0.01). The highest drug resistance rate in UU group and UU-MH mixed infection group was 31.33% (Ofloxacin) and 90.48% (Azithromycin) respectively. UU-MH mixed infection showed an increased drug resistance and changes of drug resistance spectrum.
为探讨解脲脲原体（UU）和人型支原体（MH）混合感染对7种抗菌药物的敏感性及其与非淋菌性尿道炎（NGU）患者UU感染的比较，采用微量稀释法测定体外敏感性，并对阳性结果进行分析。结果显示，UU感染组和UU-MH混合感染组对7种抗菌药物的敏感性顺序基本相同，从高到低依次为：交沙霉素、多西环素、米诺环素、司帕沙星、罗红霉素、氧氟沙星和阿奇霉素。UU-MH混合感染组的总耐药率（97.67%）显著高于UU感染组（44.67%，P<0.01）。UU组和UU-MH混合感染组的最高耐药率分别为31.33%（氧氟沙星）和90.48%（阿奇霉素）。UU-MH混合感染呈现出耐药性增加和耐药谱变化。
