Pascu M L, Danaila L, Voicu L, Staicu A, Truica S, Ion R M
National Institute for Lasers, Plasma and Radiation Physics, P.O. Box MG-36, 76900 Bucharest, Romania.
Oftalmologia. 2003;57(2):73-80.
The photodynamic therapy (PDT) became more and more widely used in the treatment of different malignant tumors. For present studies, porphyrins and haematoporphyrin derivatives, in the conditions of N2 laser radiation, were chosen because their strong absorption along a large spectral range; this makes possible the excitation of their fluorescence at 337.1 nm, which is the wavelength of the N2 pulsed laser radiation. The photophysical and photochemical properties depend on the central metal and the peripheral substituents. Trying to find an optimal sensitizer to be used with N2 laser in photodynamic therapy (PDT), a spectroscopic study of these dyes was performed. The obtained data show that the UV radiation emitted by a N2 pulsed laser may be used for PDT application; among other dyes having interesting characteristics, Zn-TSPP and Zn-TNP in DMSO at 0.5% concentration seem to be more relevant.
光动力疗法（PDT）在不同恶性肿瘤的治疗中应用越来越广泛。在目前的研究中，选择卟啉和血卟啉衍生物，在氮气激光辐射条件下，是因为它们在较宽光谱范围内有强烈吸收；这使得在337.1nm激发其荧光成为可能，337.1nm是氮气脉冲激光辐射的波长。光物理和光化学性质取决于中心金属和周边取代基。为了寻找在光动力疗法（PDT）中与氮气激光配合使用的最佳敏化剂，对这些染料进行了光谱研究。获得的数据表明，氮气脉冲激光发出的紫外线辐射可用于光动力疗法；在具有有趣特性的其他染料中，浓度为0.5%的二甲基亚砜中的锌-四磺酸基苯基卟啉（Zn-TSPP）和锌-四硝基苯基卟啉（Zn-TNP）似乎更具相关性。
