Bhugra D, Hutchinson G, Hilwig M, Takei N, Fahy T A, Neehall J, Murray R M
West Indian Med J. 2003 Jun;52(2):124-6.
It has been shown that an excess of pregnancy and birth complications (PBCs) does not contribute to the excess rates of schizophrenia reported for the population of Caribbean origin in Britain compared with the native Caucasian British population. We therefore attempted to compare the rate of PBCs between a sample of schizophrenics in Britain with that of a sample from Trinidad where some of the Caribbean migrants to Britain originated. First contact patients with schizophrenia according to the CATEGO system diagnosis were identified in Trinidad and London. Their mothers, where available, were interviewed using the Lewis-Murray scale for pregnancy and birth complications. Data from Trinidad and Tobago concerning 56 patients were compared with those of the Caucasian (n = 61) and African-Caribbean (n = 50) patients in London. The rate of PBCs was similar for the Caucasian British patients (24.6%) and the patients in Trinidad and Tobago (21.7%). The rates were lowest in the African-Caribbean patients in London (14.0%), though this difference was not statistically significant. These findings suggest that pregnancy and birth complications are a risk factor for a substantial minority of patients with schizophrenia in Trinidad and London. It also confirms that the excess rates of schizophrenia reported for the Caribbean population in Britain are not due to these complications.
研究表明，与英国本土白种人群相比，加勒比裔英国人群中报告的精神分裂症发病率过高并非由过多的妊娠和分娩并发症（PBCs）导致。因此，我们试图比较英国精神分裂症患者样本与特立尼达样本（一些移民到英国的加勒比人来自此地）中的PBCs发生率。根据CATEGO系统诊断，在特立尼达和伦敦确定了首次就诊的精神分裂症患者。在可行的情况下，使用Lewis-Murray妊娠和分娩并发症量表对他们的母亲进行访谈。将特立尼达和多巴哥56例患者的数据与伦敦的白种人患者（n = 61）和非裔加勒比人患者（n = 50）的数据进行比较。英国白种人患者的PBCs发生率（24.6%）与特立尼达和多巴哥患者的发生率（21.7%）相似。伦敦非裔加勒比人患者的发生率最低（14.0%），不过这一差异无统计学意义。这些发现表明，妊娠和分娩并发症是特立尼达和伦敦相当一部分精神分裂症患者的危险因素。这也证实了英国加勒比人群中报告的精神分裂症发病率过高并非由这些并发症所致。
