Abraham Daryn, McGrath Kris G
Division of Allergy-Immunology, Ernest S. Bazley Asthma and Allergic Diseases Center, Department of Medicine, Northwestern Memorial Hospital, USA.
Allergy Asthma Proc. 2003 Jul-Aug;24(4):291-4.
Aldesleukin is a human recombinant interleukin-2 product. It also is known as interlukin-2 and Proleukin in the United States. It is indicated for the treatment of adults with metastatic renal cell carcinoma as well as for adults with metastatic melanoma. However, its use has been limited because of severe systemic toxicity. There have been no reports of aldesleukin producing a hypersensitivity reaction. This is the first reported case of an immediate systemic hypersensitivity reaction occurring after aldesleukin administration confirmed by enzyme-linked immunosorbent assay for specific immunoglobulin E against aldesleukin.
阿地白介素是一种人重组白细胞介素-2产品。在美国，它也被称为白细胞介素-2和普罗力。它适用于治疗成人转移性肾细胞癌以及成人转移性黑色素瘤。然而，由于严重的全身毒性，其应用受到限制。此前尚无阿地白介素产生超敏反应的报道。这是首例经针对阿地白介素的特异性免疫球蛋白E的酶联免疫吸附测定证实，在使用阿地白介素后发生即刻全身超敏反应的病例报告。
