Kim Jin, Liu Kwang-Hyeon, Kang Seung-Hun, Koo Suk-Jin, Kim Jeong-Han
School of Agricultural Biotechnology, Seoul National University, 103 Seodundong, Suwon 441-744, Korea.
Pest Manag Sci. 2003 Sep;59(9):1037-42. doi: 10.1002/ps.709.
LGC-42153, 2-fluoro-1-[3-(4,6-dimethoxypyrimidin-2-ylcarbamoylsulfamoyl)pyridin-2-yl] propyl methoxyacetate, is a new sulfonylurea herbicide for use in rice. Its breakdown and metabolism was studied in soil under flooded conditions using two radioactive tracer compounds labelled at either the propyl group or the pyrimidine ring. The half-life of LGC-42153 was approximately 3.0 days. The mass balance over 120 days ranged from 94.0 to 104.2% of applied radiocarbon, and no significant amount of volatiles or [14C]carbon dioxide were observed. Solvent non-extractable radiocarbon reached about 11-14% of applied radiocarbon at 120 days after treatment. The major metabolic reaction was the cleavage of the carboxyl ester bond to give 1-(4,6-dimethoxypyrimidin-2-yl)-3-[2-(1-hydroxy-2-fluoropropyl)pyridine-3-sulfonyl]urea, which underwent hydrolysis of the sulfonylurea bridge giving 2-(1-hydroxy-2-fluoro)propyl-3-pyridinesulfonamide and 4,6-dimethoxy-2-aminopyrimidine.
LGC - 42153，即2 - 氟 - 1 - [3 - (4,6 - 二甲氧基嘧啶 - 2 - 基氨基甲酰基氨磺酰基)吡啶 - 2 - 基]丙基甲氧基乙酸酯，是一种用于水稻的新型磺酰脲类除草剂。使用两种分别标记在丙基或嘧啶环上的放射性示踪化合物，在淹水条件下的土壤中研究了其降解和代谢情况。LGC - 42153的半衰期约为3.0天。120天内的质量平衡范围为施入放射性碳的94.0%至104.2%，未观察到大量挥发性物质或[14C]二氧化碳。处理后120天，溶剂不可提取的放射性碳达到施入放射性碳的约11 - 14%。主要代谢反应是羧基酯键断裂，生成1 - (4,6 - 二甲氧基嘧啶 - 2 - 基)-3 - [2 - (1 - 羟基 - 2 - 氟丙基)吡啶 - 3 - 磺酰基]脲，该物质的磺酰脲桥发生水解，生成2 - (1 - 羟基 - 2 - 氟)丙基 - 3 - 吡啶磺酰胺和4,6 - 二甲氧基 - 2 - 氨基嘧啶。
