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近距离治疗中基于水吸收剂量的临床β辐射剂量测定法:国际标准化组织关于国际标准的新工作项目提案

Clinical beta radiation dosimetry for brachytherapy in terms of absorbed dose to water: ISO new work item proposal for international standardization.

作者信息

Quast Ulrich, Böhm Jürgen, Kaulich Theodor W

机构信息

Clinical Radiation Physics, Essen University Hospital, D 45122 Essen, Germany.

出版信息

Cardiovasc Radiat Med. 2002 Jul-Dec;3(3-4):209-12. doi: 10.1016/s1522-1865(03)00110-0.

DOI:10.1016/s1522-1865(03)00110-0
PMID:12974376
Abstract

PURPOSE

Beta radiation has found increasing interest in intravascular brachytherapy for successfully overcoming the severe problem of restenosis after interventional treatment of arterial stenosis. Prior to initiating procedures applying beta radiation there is a common need to specify methods for the determination and specification of the absorbed dose to water or tissue and their spatial distributions. The DIN-NAR standardization in radiology task group Dosimetry has initiated an international ad hoc working group for an ISO new work item proposal on the standardization of procedures in clinical beta radiation dosimetry.

METHODS

The intent of this standard is to review methods and to give recommendations for the calibration of therapeutic beta sources, a code of practice for clinical beta radiation dosimetry and guidance for estimating the uncertainty of the absorbed dose to water delivered. The standard will be confined to "scaled" radioactive sources such as single seeds, source trains, line, shell and volume sources for which only the beta radiation emitted is of therapeutic relevance. The topics will include dosimetric quantities; source data; calibration and traceability; general principles and requirements for absorbed dose measurements; in phantom dosimetry; theoretical modeling; presentation of dose distributions; clinical dosimetry; clinical quality control; irradiation treatment planning; as well as uncertainties. The document is geared to organizations wishing to establish reference methods in dosimetry aiming at clinical demands for appropriate small measurement uncertainties. Existing normative documents as well as international recommendations, such as those from AAPM, DGMP, ESTRO, NCS, ICRU, or IAEA will be taken into account.

RESULTS

The first meetings of the new international working group took place in March and September 2002 at Essen, Germany [IAEA-cn-96-73, 2002].

CONCLUSIONS

Based on the DGMP Report 16, the AAPM TG 60 up-date draft, other recommendations and normative documents, the DIN-NAR project has collected and prepared detailed material on the calibration and dosimetry of beta radiation brachytherapy sources in terms of absorbed dose to water. The ISO new work item proposal will be completed in spring 2003.

摘要

目的

β射线在血管内近距离放射治疗中越来越受到关注,因为它能成功克服动脉狭窄介入治疗后再狭窄这一严重问题。在启动应用β射线的程序之前,通常需要确定测定水或组织中吸收剂量及其空间分布的方法并加以规范。放射学剂量测定任务组的德国标准化学会(DIN-NAR)已发起成立一个国际特别工作组,就临床β射线剂量测定程序的标准化提出国际标准化组织(ISO)新工作项目提案。

方法

本标准的目的是审查相关方法,并就治疗性β源的校准、临床β射线剂量测定的操作规范以及估算水吸收剂量的不确定性提供指导。该标准将仅限于“标准化”放射性源,如单粒籽源、源链、线状源、壳状源和体源,对于这些源,只有发射的β射线具有治疗相关性。主题将包括剂量学量;源数据;校准与可追溯性;吸收剂量测量的一般原则和要求;模体剂量测定;理论建模;剂量分布的呈现;临床剂量测定;临床质量控制;照射治疗计划;以及不确定性。该文件面向希望建立剂量测定参考方法的组织,以满足临床对适当小测量不确定性的需求。将考虑现有的规范性文件以及国际建议,如美国医学物理学家协会(AAPM)、德国医学物理与工程学会(DGMP)、欧洲放射肿瘤学会(ESTRO)、核计量委员会(NCS)、国际辐射单位与测量委员会(ICRU)或国际原子能机构(IAEA)的建议。

结果

新国际工作组的首次会议于2002年3月和9月在德国埃森举行[国际原子能机构-cn-96-73,2002]。

结论

基于DGMP报告16、AAPM TG 60更新草案、其他建议和规范性文件,DIN-NAR项目已收集并准备了关于β射线近距离放射治疗源以水吸收剂量表示的校准和剂量测定方面的详细材料。ISO新工作项目提案将于2003年春季完成。

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