Miles John M
Mayo Medical School, Rochester, Minnesota, USA.
J Assoc Physicians India. 2003 May;51:501-5.
Improved glycemic control reduces microvascular complications in both type 1 and type 2 diabetes. Macrovascular complications predominate in type 2 diabetes, and the effect of tight control here is less clear. Treatment of other aspects of insulin resistance (BP, lipids) significantly reduces cardiovascular morbidity and mortality in type 2 diabetes. Insulin therapy has favorable effects on endothelial function and lipids, especially compared with sulfonylureas. More information is needed on the effects of diabetes pharmacotherapy on cardiovascular outcomes.
改善血糖控制可减少1型和2型糖尿病的微血管并发症。大血管并发症在2型糖尿病中更为常见，严格控制血糖在此方面的效果尚不清楚。治疗胰岛素抵抗的其他方面（血压、血脂）可显著降低2型糖尿病患者的心血管发病率和死亡率。胰岛素治疗对内皮功能和血脂有有利影响，尤其是与磺脲类药物相比。关于糖尿病药物治疗对心血管结局的影响，还需要更多信息。
