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大鼠中脂肪酸结合蛋白6(Fabp6)及其无内含子片段的测序与染色体定位

Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat.

作者信息

Bonné Anita, Gösele Claudia, den Bieman Maria, Gillissen Gert, Kreitler Thomas, Pravenec Michal, Kren Vladimir, van Lith Hein, van Zutphen Bert

机构信息

Department of Laboratory Animal Science, Faculty of Veterinary Science, Utrecht University, P.O. Box 80166, 3508 TD Utrecht, The Netherlands.

出版信息

Mol Biol Rep. 2003 Sep;30(3):173-6. doi: 10.1023/a:1024968606162.

Abstract

The fatty acid binding protein 6 gene (Fabp6) codes for ileal lipid binding protein. After sequencing of rat Fabp6, the gene was localized in a radiation hybrid (RH) map on chromosome 10. An intronless Fabp6 segment was found in four related rat inbred strains (SHR; SHRSP; WKY; and OKA), but not in 62 other rat inbred strains. The intronless Fabp6 segment, which might be a pseudogene of Fabp6, was localized on rat chromosome 15.

摘要

脂肪酸结合蛋白6基因(Fabp6)编码回肠脂质结合蛋白。对大鼠Fabp6进行测序后,该基因定位在10号染色体的辐射杂种(RH)图谱上。在四个相关的大鼠近交系(SHR;SHRSP;WKY;和OKA)中发现了一个无内含子的Fabp6片段,但在其他62个大鼠近交系中未发现。这个可能是Fabp6假基因的无内含子Fabp6片段定位在大鼠15号染色体上。

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