Gommerman Jennifer L, Browning Jeffrey L
Biogen, Department of Exploratory Sciences, 12 Cambridge Center, Cambridge, Massachusetts 02142, USA.
Nat Rev Immunol. 2003 Aug;3(8):642-55. doi: 10.1038/nri1151.
Much of the efficiency of the immune system is attributed to the high degree of spatial and temporal organization in the secondary lymphoid organs. Signalling through the lymphotoxin (LT) pathway is a crucial element in the maintenance of this organized microenvironment. The effect of altering lymphoid microenvironments on immune responses remains relatively unexplored. Inhibitors of the LT and LIGHT pathways have been shown to reduce disease in a wide range of autoimmune models. This approach has provided a tool to probe the effect of manipulation of the microenvironment on both normal and pathological immune responses.
免疫系统的大部分效率归因于次级淋巴器官中高度的空间和时间组织。通过淋巴毒素（LT）途径发出信号是维持这种有组织的微环境的关键因素。改变淋巴微环境对免疫反应的影响仍相对未被探索。LT和LIGHT途径的抑制剂已被证明能在多种自身免疫模型中减轻疾病。这种方法提供了一种工具，用于探究微环境操纵对正常和病理性免疫反应的影响。
