Mostowska Adrianna, Kobielak Agnieszka, Trzeciak Wieslaw H
Department of Biochemistry and Molecular Biology University of Medical Sciences, Poznan, Poland.
Eur J Oral Sci. 2003 Oct;111(5):365-70. doi: 10.1034/j.1600-0722.2003.00069.x.
Tooth agenesis constitutes the most common anomalies of dental development in man. Despite this, little is known about the genetic defects responsible for this complex condition. To date, the only genes associated with the non-syndromic form of tooth agenesis are MSX1 and PAX9, which encode transcription factors that play a critical role during tooth development. This paper aims to review current literature about the molecular mechanisms responsible for selective tooth agenesis in humans.
牙齿发育不全是人类最常见的牙齿发育异常。尽管如此，对于导致这种复杂情况的基因缺陷却知之甚少。迄今为止，与非综合征型牙齿发育不全相关的唯一基因是MSX1和PAX9，它们编码在牙齿发育过程中起关键作用的转录因子。本文旨在综述目前关于人类选择性牙齿发育不全分子机制的文献。
