Barbour Michele E, Parker David M, Allen Geoff C, Jandt Klaus D
University of Bristol, Department of Oral and Dental Science, Biomedical Engineering and Biomaterials Science Section, Bristol, UK.
Eur J Oral Sci. 2003 Oct;111(5):428-33. doi: 10.1034/j.1600-0722.2003.00059.x.
The aim of this study was to investigate enamel dissolution in citric acid solutions as a function of solution calcium and phosphate concentrations and degree of saturation with respect to hydroxyapatite (DSHA). The primary relevance of the study is the development of soft drinks with reduced erosive potential. Nanoindentation was used to investigate changes in the hardness of polished human enamel surfaces after 120 s and 300 s exposure to solutions with pH 3.30 and a range of calcium and phosphate concentrations. All solutions were undersaturated with respect to hydroxyapatite, with 0.000 < or = DSHA < or = 0.295. A complex dependence of enamel softening on calcium concentration was observed. Substantial enamel softening occurred in solutions with calcium concentrations equal to or less than 120 mm (DSHA approximately 0.104), but there was little or no statistically significant softening of the enamel for calcium concentrations over 120 mm. This condition may be applicable to soft drink formulation. Furthermore, solutions with DSHA = 0.101 and different calcium/phosphate ratios resulted in different degrees of softening of the enamel. Hence, contrary to assumptions made in many models, enamel dissolution is not simply a function of DSHA, and individual calcium and phosphate concentrations are critical.
本研究的目的是探究柠檬酸溶液中牙釉质的溶解情况，该溶解情况是溶液中钙和磷酸盐浓度以及相对于羟基磷灰石的饱和度（DSHA）的函数。本研究的主要意义在于开发具有较低侵蚀潜力的软饮料。使用纳米压痕技术研究了在pH值为3.30且钙和磷酸盐浓度范围不同的溶液中暴露120秒和300秒后，抛光的人牙釉质表面硬度的变化。所有溶液相对于羟基磷灰石均不饱和，0.000≤DSHA≤0.295。观察到牙釉质软化对钙浓度存在复杂的依赖性。在钙浓度等于或小于120 mmol/L（DSHA约为0.104）的溶液中，牙釉质发生显著软化，但对于钙浓度超过120 mmol/L的情况，牙釉质几乎没有或没有统计学上显著的软化。这种情况可能适用于软饮料配方。此外，DSHA = 0.101且钙/磷酸盐比例不同的溶液导致牙釉质不同程度的软化。因此，与许多模型中的假设相反，牙釉质溶解不仅仅是DSHA的函数，单个钙和磷酸盐浓度至关重要。
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