Gentilcore Diana, O'Donovan Deirdre, Jones Karen L, Horowitz Michael
Department of Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia.
Curr Diab Rep. 2003 Oct;3(5):418-26. doi: 10.1007/s11892-003-0087-9.
The management of diabetic gastroparesis often represents a significant clinical challenge in which the maintenance of nutrition is pivotal. Gastric emptying is delayed in 30% to 50% of patients with longstanding type 1 or type 2 diabetes and upper gastrointestinal symptoms also occur frequently. However, there is only a weak association between the presence of symptoms and delayed gastric emptying. Acute changes in blood glucose concentrations affect gastric motility in diabetes; hyperglycemia slows gastric emptying whereas hypoglycemia may accelerate it; blood glucose concentrations may also influence symptoms. It is now recognized that gastric emptying is a major determinant of postprandial glycemia and, therefore, there is considerable interest in the concept of modulating gastric emptying, by dietary or pharmacologic means, to optimize glycemic control in diabetes.
糖尿病性胃轻瘫的管理常常是一项重大的临床挑战，其中营养维持至关重要。在30%至50%的长期1型或2型糖尿病患者中，胃排空延迟，上消化道症状也经常出现。然而，症状的存在与胃排空延迟之间的关联较弱。血糖浓度的急性变化会影响糖尿病患者的胃动力；高血糖会减慢胃排空，而低血糖可能会加速胃排空；血糖浓度也可能影响症状。现在人们认识到，胃排空是餐后血糖的主要决定因素，因此，通过饮食或药物手段调节胃排空以优化糖尿病患者的血糖控制这一概念备受关注。
