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[临床及亚临床甲状腺功能亢进症的发病率及特征]

[Incidence and characteristics of clinical and sub-clinic hyperthyroidism].

作者信息

Soler Solé M N, Godoy P, Amorós Brotons M, Sarriegui Domínguez S, Rius Riu F

机构信息

Médico de Familia. Centro de Atención Primaria del Institut Català de la Salut. ABS Bordeta-Magraners. Lleida. España.

出版信息

Aten Primaria. 2003;32(4):203-7. doi: 10.1016/s0212-6567(03)79253-1.

Abstract

OBJECTIVES

Estimate the incidence of hyperthyroidism in the region of Lleida and compare patients with clinic and subclinic hyperthyroidism.

DESIGN

Descriptive retrospective.

LOCALIZATION

City of Lleida and the towns of the provinces of Lleida and Huesca.

PATIENTS

190 people diagnosed of hyperthyroidism detected from a sample of 1885 patients with different pathologies, belonging to first visits to de Service of Endocrinology of the Hospital Arnau de Vilanova, during the period from 1999 to 2000.

MAIN MEASUREMENTS

The following clinic and demographical variables related to the thyroid pathology were recorded: TSH, T(4), T(3), anti-Tg antibodies, anti-TPO antibodies, age, gender, consumption of salt with iodine and the incidence tax of hyperthyroidism.

RESULTS

The incidence tax of hyperthyroidism in the province of Lleida was 46.2 ×10(5) people/year (95% CI, 33.5-61.0). For the 190 patients, the 85% (95% CI, 79.4-90) of them were women; the 38% (95% CI, 31%-45.2%) and the 62% (95% CI, 54.8-69) were diagnosed of clinic and subclinic hyperthyroidism respectively. The subclinic profile was characteristically for had a superior mean of age (P<.003), double of TSH level (P<.03) and half of T(4) level of (P<.001).

CONCLUSION

Our study shows a high incidence of hyperthyroidism, and a difference of the two hyperthyroidisms. The detection of this pathology by professionals of primary care can help to improve their therapeutic control.

摘要

目的

估算莱里达地区甲状腺功能亢进症的发病率,并比较临床甲亢患者和亚临床甲亢患者。

设计

描述性回顾研究。

地点

莱里达市以及莱里达省和韦斯卡省的城镇。

患者

190例被诊断为甲状腺功能亢进症的患者,这些患者来自1885例患有不同疾病的患者样本,均为1999年至2000年期间首次到阿诺·德·比拉诺瓦医院内分泌科就诊的患者。

主要测量指标

记录以下与甲状腺疾病相关的临床和人口统计学变量:促甲状腺激素(TSH)、甲状腺素(T4)、三碘甲状腺原氨酸(T3)、抗甲状腺球蛋白抗体、抗甲状腺过氧化物酶抗体、年龄、性别、碘盐摄入量以及甲状腺功能亢进症的发病率。

结果

莱里达省甲状腺功能亢进症的发病率为46.2×10⁵人/年(95%可信区间,33.5 - 61.0)。在这190例患者中,85%(95%可信区间,79.4 - 90)为女性;分别有38%(95%可信区间,31% - 45.2%)和62%(95%可信区间,54.8 - 69)的患者被诊断为临床甲亢和亚临床甲亢。亚临床甲亢患者的特征是平均年龄较高(P <.003)、TSH水平加倍(P <.03)以及T4水平减半(P <.001)。

结论

我们的研究显示甲状腺功能亢进症的发病率较高,且两种甲亢类型存在差异。初级保健专业人员对这种疾病的检测有助于改善其治疗控制。

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