抗代谢药物在青光眼手术治疗中的应用
Antimetabolites in the surgical treatment of glaucomas.
作者信息
Van Oye R, Van Caelenberghe E
机构信息
University Hospital of Ghent, Department of Ophthalmology, Belgium.
出版信息
Bull Soc Belge Ophtalmol. 1992;244:161-8.
PMID:1297509
Abstract
Fibroblast proliferation with scarring at the surgical site plays an important role in the failure of filtration surgery. Several antimetabolites inhibit fibroblast proliferation in vitro. These observations have lead to the widespread clinical use in humans of 5-fluorouracil and more recently mitomycin-C in glaucoma filtering surgery.
摘要
手术部位的成纤维细胞增殖伴瘢痕形成在滤过性手术失败中起重要作用。几种抗代谢物在体外可抑制成纤维细胞增殖。这些观察结果已导致5-氟尿嘧啶以及最近丝裂霉素-C在青光眼滤过手术中在人类中的广泛临床应用。
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