Fosko Scott W, Hu Weimin, Cook Thomas F, Lowe Val J
Department of Dermatology, Saint Louis University Health Sciences Center, MO 63104, USA.
Arch Dermatol. 2003 Sep;139(9):1141-6. doi: 10.1001/archderm.139.9.1141.
To determine the ability of fluorodeoxyglucose F 18 positron emission tomography (FDG-PET) to image basal cell carcinoma (BCC).
Case series study.
Mohs surgery practice in a tertiary university hospital.
Six patients with BCC larger than 1.0 cm of the head and neck region were identified.
Patients were imaged using FDG-PET before surgery. In 3 patients, PET imaging correlated well with the size and extent of the soft tissue invasion. Histologically, all 3 tumors were of the nodular subtype. The remaining 3 patients failed to demonstrate identifiable tumor activity on PET. Two of these 3 tumors were of the infiltrative histologic subtype, and 1 was of the nodular subtype. Perineural spread was detected by tissue biopsy in 1 infiltrative tumor, but not by FDG-PET imaging.
In our study, FDG-PET imaging was able to image and identify BCC in the head and neck region in 3 of 6 patients. In some cases, anatomic accuracy and the extent of soft tissue invasion were observed. The histologic subtype of the BCC appears to affect the ability of FDG-PET detection, with the nodular histologic subtype more likely to test positive on PET. This is a preliminary study, and future investigation is needed to evaluate the role of PET imaging in the management of patients with BCC.
确定氟脱氧葡萄糖F 18正电子发射断层扫描（FDG-PET）对基底细胞癌（BCC）进行成像的能力。
病例系列研究。
一所三级大学医院的莫氏手术科室。
确定了6例头颈部基底细胞癌直径大于1.0 cm的患者。
患者在手术前接受了FDG-PET成像。3例患者中，PET成像与软组织浸润的大小和范围相关性良好。组织学检查显示，所有3例肿瘤均为结节型。其余3例患者在PET上未显示可识别的肿瘤活性。这3例肿瘤中有2例为浸润型组织学亚型，1例为结节型。在1例浸润性肿瘤中，通过组织活检检测到神经周围扩散，但FDG-PET成像未检测到。
在我们的研究中，FDG-PET成像能够在6例患者中的3例对头颈部基底细胞癌进行成像和识别。在某些情况下，观察到了解剖学准确性和软组织浸润范围。基底细胞癌的组织学亚型似乎会影响FDG-PET检测的能力，结节型组织学亚型在PET上更有可能呈阳性。这是一项初步研究，需要进一步的调查来评估PET成像在基底细胞癌患者管理中的作用。
