[剂量率对吸入氡气后大鼠肿瘤诱发作用的重要性]
[Importance of the role of dose rate on tumor induction in rats after radon inhalation].
作者信息
Morlier J P, Morin M, Chameaud J, Masse R, Bottard S, Lafuma J
机构信息
C.E.A.-C.E.N.F.A.R., Fontenay-aux-Roses.
出版信息
C R Acad Sci III. 1992;315(12):463-6.
PMID:1297522
Abstract
Lung cancer can be induced in rats, by radon daughter products, after exposure as low as 25 WLM (80 mJ.h.m-3) protracted over 4 to 6 months with a dose rate of 100 to 150 WL (2 to 3 mJ.m-3). The incidence of lung cancer is not increased and is equal to that of controls when the same cumulated dose is protracted over 18 months at 2 WL (0.042 mJ.m-3).
摘要
当大鼠暴露于低至25工作水平月（80毫焦·小时·立方米⁻¹）的氡子体，剂量率为100至150工作水平（2至3毫焦·立方米⁻¹），持续4至6个月时，可诱发肺癌。当相同的累积剂量在18个月内以2工作水平（0.042毫焦·立方米⁻¹）持续给予时，肺癌发病率并未增加，且与对照组相同。
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