Vion-Dury J, Mouly-Bandini A, Viout P, Sciaky M, Confort-Gouny S, Montiès J R, Cozzone P
Centre de Résonance magnétique biologique et médicale, U.R.A.-C.N.R.S. n. 1186, Faculté de Médecine, Marseille.
C R Acad Sci III. 1992;315(12):479-84.
Early diagnosis of acute cardiac graft rejection by non-invasive methods is required for medical, organizational, psychological and economic reasons. We have monitored 18 heart recipients over a period of 2.5 years using endomyocardial biopsies (EMB), cardiac Doppler-echography (CDE) and proton NMR spectroscopy assay of plasma glycosylated residues. Diastolic parameters of CDE and assay of the glycosylated residues by NMR spectroscopy respectively detect 42 and 45% of the acute low grade (mild or moderate) histological rejections. The combination of the two methods allows the detection of 65% of rejections. The strategy combining plasma NMR spectroscopy and echography is pertinent to the non-invasive detection of acute cardiac rejections with low histological grade.
出于医学、组织、心理和经济等方面的原因，需要通过非侵入性方法对急性心脏移植排斥反应进行早期诊断。我们在2.5年的时间里，使用心内膜心肌活检（EMB）、心脏多普勒超声心动图（CDE）和血浆糖基化残基的质子核磁共振波谱分析，对18名心脏移植受者进行了监测。CDE的舒张参数和通过核磁共振波谱分析糖基化残基分别检测出42%和45%的急性低度（轻度或中度）组织学排斥反应。两种方法结合可检测出65%的排斥反应。将血浆核磁共振波谱分析和超声心动图相结合的策略适用于对低组织学分级的急性心脏排斥反应进行非侵入性检测。
