追踪糖尿病中的自身免疫性T细胞。
Tracking autoimmune T cells in diabetes.
作者信息
Serreze David V, Leiter Edward H
机构信息
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.
出版信息
J Clin Invest. 2003 Sep;112(6):826-8. doi: 10.1172/JCI19842.
Abstract
Insulin-dependent diabetes mellitus is usually caused by the autoimmune destruction of pancreatic beta cells by T cells. Methodologies to track the development, migration, and functional activation of one class of such T cells (CD4 T cells) have been limited. However, it now appears that this limitation has been overcome.
摘要
胰岛素依赖型糖尿病通常是由T细胞对胰腺β细胞的自身免疫性破坏所致。追踪这类T细胞（CD4 T细胞）中一类细胞的发育、迁移和功能激活的方法一直有限。然而，现在看来这一限制已被克服。
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本文引用的文献
1
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.易感性主要组织相容性复合体（MHC）等位基因而非背景基因，选择了一种自身免疫性T细胞反应性。
J Clin Invest. 2003 Sep;112(6):902-14. doi: 10.1172/JCI18337.
2
Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.在自身免疫性糖尿病中未能清除CD4 T细胞的禁忌克隆。
J Exp Med. 2002 Nov 4;196(9):1175-88. doi: 10.1084/jem.20020735.
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Two mechanisms for the non-MHC-linked resistance to spontaneous autoimmunity.非主要组织相容性复合体（MHC）连锁的自发性自身免疫抗性的两种机制。
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