Tamada Renata S, Lafer Beny
Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. São Paulo, SP, Brasil.
Braz J Psychiatry. 2003 Sep;25(3):171-6. doi: 10.1590/s1516-44462003000300010.
To review the literature on antidepressant-induced mania, its incidence, clinical presentation, risk factors and treatment.
A Medline search of studies published between 1970 and 2001 was carried out. Open and controlled studies as well as case series with data from more than five patients were included.
Antidepressant induced mania may differ clinically from spontaneous mania with a milder severity and shorter duration. The risk factors have not been established.
A very limited number of prospective and controlled studies on antidepressant-induced mania have been published. Antidepressants have been associated with an increased risk of inducing mania. This risk may vary according to the drug utilized. Therefore antidepressants should be used in bipolar patients based on clinical efficacy as well as the potential effects on the course of the illness.
回顾关于抗抑郁药诱发躁狂的文献，包括其发病率、临床表现、危险因素及治疗。
对1970年至2001年间发表的研究进行Medline检索。纳入开放性和对照性研究以及病例系列（病例数超过5例）。
抗抑郁药诱发的躁狂在临床上可能与自发性躁狂不同，严重程度较轻且持续时间较短。危险因素尚未明确。
关于抗抑郁药诱发躁狂的前瞻性和对照性研究发表数量非常有限。抗抑郁药与诱发躁狂的风险增加有关。这种风险可能因所用药物而异。因此，在双相情感障碍患者中使用抗抑郁药时应基于临床疗效以及对病程的潜在影响。
