Meerson F Z, Krasikov S I, Chavkin I I, Bikbulatov M S, Tverdokhlib V P
Kardiologiia. 1992;32(11-12):78-82.
Adaptation to intermittent hypoxia in the hypobaric altitude chamber showed a two-fold decrease in ethanol consumption in chronically alcoholized rats and attenuated or arrested the withdrawal syndrome. The impact of adaptation to the withdrawal syndrome was that it prevented the development of withdrawal analgesia, higher alcohol consumption after its withdrawal, withdrawal hepatic activation of lipid oxidation products and blood release of the hepatic specific enzymes fructose monophosphataldolase and gamma-glutamyl transpeptidase. Concurrently, the adaptation prevented the withdrawal fall of the cardiac fibrillation threshold and marked disorders of ventricular contraction and relaxation. The paper discusses whether adaptation to intermittent hypoxia can be used in the management of the types of alcoholism in whose development the withdrawal plays the key role.
在低压舱中适应间歇性低氧显示，长期酒精化的大鼠乙醇消耗量减少了两倍，并减轻或阻止了戒断综合征。适应对戒断综合征的影响在于，它阻止了戒断性镇痛的发展、戒断后更高的酒精消耗量、戒断时肝脏脂质氧化产物的激活以及肝脏特异性酶果糖单磷酸醛缩酶和γ-谷氨酰转肽酶的血液释放。同时，这种适应阻止了房颤阈值的戒断性下降以及心室收缩和舒张的明显紊乱。本文讨论了适应间歇性低氧是否可用于治疗那些在其发展过程中戒断起关键作用的酒精中毒类型。
