Omeke B C, Onuora G I
Department of Veterinary Physiology and Pharmacology, University of Nigeria Nsukka.
Rev Elev Med Vet Pays Trop. 1992;45(1):27-30.
Sixty adult male guinea-pigs were used to study the effect of Trypanosoma brucei brucei and Trypanosoma congolense infections on genitalia, testicles and reproductive capacity. Both infections showed acute to chronic courses. T. b. brucei appeared more virulent than T. congolense. In both cases the infection periods significantly (P < 0.01) influenced resultant decrease in body and gonadal weight, testicular mass index and extent of lesion formation. Histopathological lesions included mononuclear infiltration, distortion of seminiferous tubules and degeneration of germ cells. Both trypanosomes impaired reproductive capacity through impaired hormone biosynthesis, sperm production and reserves. Use of guinea-pigs as a laboratory model for the study of trypanosomosis in domestic animals is discussed.
使用60只成年雄性豚鼠研究布氏布氏锥虫和刚果锥虫感染对生殖器、睾丸及生殖能力的影响。两种感染均呈现从急性到慢性的病程。布氏布氏锥虫似乎比刚果锥虫毒性更强。在两种情况下，感染期均显著（P < 0.01）影响体重和性腺重量的下降、睾丸质量指数以及病变形成程度。组织病理学病变包括单核细胞浸润、生精小管扭曲和生殖细胞变性。两种锥虫均通过损害激素生物合成、精子生成和储备而损害生殖能力。文中讨论了将豚鼠用作研究家畜锥虫病的实验室模型的情况。
