Geus W P, Vinks A A, Lamers C B
Dept. of Gastroenterology, Leyenburg Hospital, The Hague, The Netherlands.
Scand J Gastroenterol Suppl. 1992;194:55-8. doi: 10.3109/00365529209096027.
The pharmacokinetics of ranitidine during two different modes of intravenous administration was studied in a homogeneous group of postoperative intensive care unit patients (n = 18). Patients at risk of developing stress-related lesions were randomized to receive repeated injections, 50 mg every 6 h (group A), or a continuous infusion, 50-mg bolus followed by 0.125 mg/kg/h (group B). Before treatment all patients received a single 50-mg ranitidine dose. Serum ranitidine concentrations were measured for 12 h after the single dose and during the treatment period, to calculate individual pharmacokinetic variables. From the single-dose study the calculated half-life, volume of distribution, and clearance were 3.14 +/- 0.61 h, 1.45 +/- 0.42 l/kg, and 0.40 +/- 0.14 l/kg/h for group A and 3.33 +/- 1.08 h, 1.16 +/- 0.20 l/kg, and 0.35 +/- 0.21 l/kg/h, for group B, respectively. Ranitidine pharmacokinetics after the single dose was comparable in the two groups. No statistically significant differences could be detected between the ranitidine pharmacokinetics after the first single dose and the multiple dose or continuous infusion.
在一组同质的术后重症监护病房患者（n = 18）中，研究了雷尼替丁在两种不同静脉给药方式下的药代动力学。将有发生应激相关病变风险的患者随机分为两组，A组每6小时重复注射50毫克，B组先静脉推注50毫克，然后以0.125毫克/千克/小时的速度持续输注。治疗前，所有患者均接受单次50毫克雷尼替丁剂量。在单次给药后12小时以及治疗期间测量血清雷尼替丁浓度，以计算个体药代动力学变量。从单剂量研究中得出，A组计算出的半衰期、分布容积和清除率分别为3.14±0.61小时、1.45±0.42升/千克和0.40±0.14升/千克/小时，B组分别为3.33±1.08小时、1.16±0.20升/千克和0.35±0.21升/千克/小时。两组单次给药后雷尼替丁的药代动力学具有可比性。在首次单剂量给药后的雷尼替丁药代动力学与多次给药或持续输注后的药代动力学之间未检测到统计学上的显著差异。
