Ruaux C, Serrano E, Delisle M B, Pessey J J
Service ORL, CHU Rangueil, Toulouse.
Ann Otolaryngol Chir Cervicofac. 1992;109(6):294-302.
Authors report a retrospective study of 10 new cases of inverted papilloma of the nose and paranasal sinuses, observed during a 26 years period, with a 6.1 years average follow up. This group is marked by 2 cases of directly carcinomatous association, 4 cases of recurrence and 2 cases of later malignant transformation. The responsibility of different types of human papillomavirus in the origin of this tumor and its malignant transformation is suspected. Preoperative evaluation is based on clinical examination, CT scan and endoscopic method while diagnosis and prognosis depend on histopathologic finding of the whole tumor. The aim of surgical treatment is the most complete removal of the tumor with as limited after effects as possible. Lateral rhinotomy is the most favoured surgical approach versus mid facial degloving and intranasal endoscopy. No surgical patient, no removal tumor, inadequate limits, malignant papilloma and early recurrence are indications for external radiotherapy.
作者报告了一项对10例鼻及鼻窦内翻性乳头状瘤新病例的回顾性研究,这些病例是在26年期间观察到的,平均随访时间为6.1年。该组病例的特点是有2例直接合并癌、4例复发和2例后期恶变。怀疑不同类型的人乳头瘤病毒在该肿瘤的发生及其恶变中起作用。术前评估基于临床检查、CT扫描和内镜检查方法,而诊断和预后则取决于整个肿瘤的组织病理学检查结果。手术治疗的目的是尽可能完全地切除肿瘤,同时使术后影响尽可能有限。与面中部掀翻术和鼻内内镜检查相比,外侧鼻切开术是最常用的手术方法。对于未接受手术的患者、肿瘤切除不完全、切除范围不足、恶性乳头状瘤和早期复发的情况,均需进行外照射放疗。