Malatray J, Gautier E, Lundgren B, Carlsson E, Fellenius E
Eur J Pharmacol. 1977 Jan 7;41(1):13-6. doi: 10.1016/0014-2999(77)90365-x.
The effect on heart rate (HR) and blood pressure (BP) of metoprolol, propranolol and terbutaline, applied alone or in combinations was studied in spontaneously hypertensive rats. Terbutaline had little effect on BP and HR. Propranolol combined with terbutaline had no effect while metoprolol combined with terbutaline decreased BP by 48 mm Hg without affecting HR. Thus the beta2-mediated increase in peripheral vascular resistance after terbutaline was revealed by a drop in BP after beta1-blockade by metoprolol, but not when both beta1-and beta2-receptors were blocked by propranolol.
在自发性高血压大鼠中研究了美托洛尔、普萘洛尔和特布他林单独应用或联合应用对心率（HR）和血压（BP）的影响。特布他林对血压和心率影响很小。普萘洛尔与特布他林联合应用无作用，而美托洛尔与特布他林联合应用可使血压降低48 mmHg，且不影响心率。因此，在美托洛尔阻断β1受体后血压下降，揭示了特布他林后由β2介导的外周血管阻力增加，但当β1和β2受体均被普萘洛尔阻断时则未出现此现象。
