[鼻咽癌患者血清β2-微球蛋白测定。139例分析]

[Serum beta 2-microglobulin determination in nasopharyngeal carcinoma patients. An analysis of 139 cases].

作者信息

Luo Z M

机构信息

First Hospital of the State Farms in West Guangdong Zhanjiang.

出版信息

Zhonghua Er Bi Yan Hou Ke Za Zhi. 1992;27(4):239-40, 256.

PMID:1298313

Abstract

Serum beta 2-microglobulin (beta 2-M) was determined in normal adults, patients with chronic nasopharyngeal inflammation and nasopharyngeal carcinoma (NPC) by the radioimmunoassay (RIA). The mean value in normal adults was 2023.85 +/- 454.32 micrograms/L, that in patients with chronic nasopharyngeal inflammation was 3294.65 +/- 1320.89 micrograms/L. The mean value in patients with NPC was significantly higher than those in patients with chronic nasopharyngeal inflammation and normal adults (P < 0.01). But there was not significant difference between mean values of patients with chronic nasopharyngeal inflammation and normal adults (P > 0.05). It is suggested that the RIA of beta 2-M is a useful assay in the diagnosis of NPC.

摘要

采用放射免疫分析法（RIA）检测正常成年人、慢性鼻咽炎患者及鼻咽癌（NPC）患者血清β2微球蛋白（β2-M）。正常成年人血清β2-M均值为2023.85±454.32μg/L，慢性鼻咽炎患者血清β2-M均值为3294.65±1320.89μg/L。鼻咽癌患者血清β2-M均值显著高于慢性鼻咽炎患者及正常成年人（P<0.01）。但慢性鼻咽炎患者与正常成年人血清β2-M均值差异无统计学意义（P>0.05）。提示β2-M放射免疫分析法对鼻咽癌诊断有一定价值。