阿地芬宁与促甲状腺激素释放激素对大鼠垂体体外促甲状腺激素释放作用的比较。

Comparison of adiphenine and TRH effects on TSH release by rat pituitary in vitro.

作者信息

Jordan D, Ponsin G, Mornex R, Fevre M, Poncet C, Rostagnat A

出版信息

Eur J Pharmacol. 1977 Jan 7;41(1):53-8. doi: 10.1016/0014-2999(77)90370-3.

Abstract

The mechanism of action of adiphenine on in vitro rat anterior pituitary TSH release was compared to that of the physiological stimulator TRH. The comparative study showed that adiphenine and TRH were able to increase TSH release in a dose-dependent manner, had similar time courses of action for equipotent stimulating concentrations and produced similar aspects of stimulated TSH cells. However, there were several differences between the effects of adiphenine and TRH. Adiphenine action was inhibited by 20 mM K+; was not calcium dependent; was inhibited by neither thyroid hormones nor somatostatin; was little affected by energy depression. It is concluded that adiphenine probably acts near the ultimate steps of the TSH release pathway and could be a useful pharmacological tool for studying the mechanism of TSH release.

摘要

将己胺苯酯对体外培养的大鼠垂体前叶促甲状腺激素（TSH）释放的作用机制与生理性刺激物促甲状腺激素释放激素（TRH）的作用机制进行了比较。比较研究表明，己胺苯酯和TRH均能以剂量依赖的方式增加TSH释放，对于等效刺激浓度具有相似的作用时间进程，并且在受刺激的TSH细胞方面产生相似的表现。然而，己胺苯酯和TRH的作用之间存在若干差异。己胺苯酯的作用被20 mM K⁺抑制；不依赖钙；不受甲状腺激素或生长抑素的抑制；受能量抑制的影响很小。得出的结论是，己胺苯酯可能在TSH释放途径的最终步骤附近起作用，并且可能是研究TSH释放机制的有用药理学工具。