[烧伤患者淋巴细胞中白细胞介素-2及白细胞介素-2受体表达的变化]

[Changes in expression of interleukin-2 and interleukin-2 receptor in lymphocytes in patients with burns].

作者信息

Sun S R

机构信息

Central Laboratory, 304th Hospital of PLA, Beijing.

出版信息

Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1992 Sep;8(3):185-7, 247.

PMID:1298528

Abstract

IL-2 mainly combines with the IL-2R on the membrane of the lymphocyte, both to promote activation and proliferation. The expression of IL-2 and IL-2R on the lymphocyte was found to be significantly depressed after burn injury. IL-2 was decreased by 40%-60%, and the expression of IL-2R was decreased by 25%-55%, especially on the 7th day after burn. The results demonstrated that burn injury not only influenced the production of IL-2 from T helper cell, but also depressed the expression of IL-2R.

摘要

白细胞介素-2主要与淋巴细胞膜上的白细胞介素-2受体结合，既能促进激活又能促进增殖。研究发现，烧伤后淋巴细胞上白细胞介素-2和白细胞介素-2受体的表达显著降低。白细胞介素-2减少了40%-60%，白细胞介素-2受体的表达减少了25%-55%，尤其是在烧伤后的第7天。结果表明，烧伤不仅影响辅助性T细胞产生白细胞介素-2，还会降低白细胞介素-2受体的表达。