Amayo E O, Owade J N, Aluoch J R, Njeru E K
Department of Medicine, College of Health Science, University of Nairobi, Kenya.
East Afr Med J. 1992 Dec;69(12):660-2.
In a five year retrospective study of 360 patients with homozygous (SS) sickle cell disease, eighteen (5%) were found to have neurological complications. Their ages ranged from 7 months to 21 years with a mean of 11.1 +/- 6 years. Of those with neurological complications, twelve (67%) of the patients had cerebrovascular accident, six (33.3%) convulsions, three visual disturbance; one sensorineural deafness, one cerebellar degeneration and the last one confusion and hallucinations. Four of the patients had multiple neurological complications. There was only one patient with recurrence of neurological complications. Two patients were hypertransfused and up to the end of the study period none of them had any recurrence. The pattern of neurological complications are similar to that observed in other studies. However, in this study, there were fewer recurrences of neurological complications.
在一项对360例纯合子（SS）镰状细胞病患者的五年回顾性研究中，发现18例（5%）有神经系统并发症。他们的年龄从7个月到21岁不等，平均为11.1±6岁。在有神经系统并发症的患者中，12例（67%）发生了脑血管意外，6例（33.3%）有惊厥，3例有视觉障碍；1例感音神经性耳聋，1例小脑变性，最后1例有精神错乱和幻觉。4例患者有多种神经系统并发症。只有1例患者神经系统并发症复发。2例患者接受了强化输血，直到研究期结束，他们都没有任何复发。神经系统并发症的模式与其他研究中观察到的相似。然而，在这项研究中，神经系统并发症的复发较少。
