Chan W C, O'Mahoney M G, Yu D Y, Yu R Y
Tubercle. 1975 Sep;56(3):191-8. doi: 10.1016/0041-3879(75)90051-3.
Two patients who developed reversible renal failure during intermittent rifampicin therapy are described. Both had febrile reactions to rifampicin. The first was also found to have uraemia associated with swelling of the glomerular endothelial cells. The second developed tubular necrosis unassociated with haemolysis or shock. The pathogenesis of the renal lesion in these two patients, as revealed by light microscopy, immunofluorescence studies and electron microscopy, is discussed.
本文描述了两名在间歇性利福平治疗期间出现可逆性肾衰竭的患者。两人均对利福平有发热反应。第一名患者还被发现患有与肾小球内皮细胞肿胀相关的尿毒症。第二名患者出现了与溶血或休克无关的肾小管坏死。本文讨论了通过光学显微镜、免疫荧光研究和电子显微镜揭示的这两名患者肾脏病变的发病机制。
