腺苷和酸中毒对冠状动脉条的舒张作用。

Relaxation of coronary artery strips by adenosine and acidosis.

作者信息

Turnheim K, Pittner H, Kolassa N, Kraupp O

出版信息

Eur J Pharmacol. 1977 Jan 21;41(2):217-20. doi: 10.1016/0014-2999(77)90212-6.

Abstract

Cumulative dose-response curves of Ca2+-induced tension increments were studied in K+-depolarized helical strips of dog coronary arteries. Adenosine 10(-4) M reduced the Ca2+ sensitivity of the strips without altering the maximal tension with full Ca2+ activation. In contrast, acidosis of pH 7.05 significantly diminished the maximal tension with full Ca2+ activation. The relaxing effect of acidosis was almost completely abolished by 10(-4) M adenosine. It is concluded that adenosine inhibits Ca2+ influx, whereas acidosis depresses the contractile process of vascular smooth muscle directly.

摘要

在狗冠状动脉的钾离子去极化螺旋条带中研究了钙离子诱导的张力增加的累积剂量-反应曲线。10⁻⁴ M的腺苷降低了条带的钙离子敏感性，但在完全钙离子激活时不改变最大张力。相比之下，pH 7.05的酸中毒显著降低了完全钙离子激活时的最大张力。10⁻⁴ M的腺苷几乎完全消除了酸中毒的舒张作用。结论是，腺苷抑制钙离子内流，而酸中毒直接抑制血管平滑肌的收缩过程。