Niţă V, Serban M G, Wawernia E
C. Davilla University of Medicine and Pharmacy, Department of Physiopathology, Bucharest, Romania.
Rom J Intern Med. 1992 Oct-Dec;30(4):305-10.
Some mitochondrial biochemical parameters were determined in Wistar rats with experimentally induced arterial hypertension (AHT) treated with calcium blocking agents of the Verapamil series. The results obtained showed that succinic dehydrogenase (SDH) activity increased, in the group with AHT, by 23.4% as compared with the control group while in the group with AHT treated with Verapamil the activity of this enzyme increased by 46.7%. The NAD+ dehydrogenase activity showed a moderate increase (15.7%) in the group with AHT and an increase by 22.3% after administration of Verapamil. The mitochondrial content in thiolic groups presented an increase of 12.5% in the group with AHT and of 24.4% in the treated group. The kinetics of the mitochondrial swelling-contraction also presented changes in as much as the cycle period, first increased then partially returned to normal values after Verapamil treatment. The strongly stimulating effect of Verapamil on the enzymatic activity in the Krebs cycle was also demonstrated.
在实验性诱导动脉高血压（AHT）的Wistar大鼠中，测定了一些线粒体生化参数，这些大鼠用维拉帕米系列钙阻滞剂进行治疗。所得结果表明，与对照组相比，AHT组的琥珀酸脱氢酶（SDH）活性增加了23.4%，而在用维拉帕米治疗的AHT组中，该酶的活性增加了46.7%。NAD+脱氢酶活性在AHT组中适度增加（15.7%），在给予维拉帕米后增加了22.3%。硫醇基团中的线粒体含量在AHT组中增加了12.5%，在治疗组中增加了24.4%。线粒体肿胀-收缩的动力学也出现了变化，因为循环周期先是增加，然后在维拉帕米治疗后部分恢复到正常值。还证实了维拉帕米对三羧酸循环中酶活性有强烈的刺激作用。
