Velez de la Calle J F, Bauché F, Jégou B
GERM (Groupe d'Etude de la Reproduction chez le Mâle), Université de Rennes I. INSERM CJF 91-04.
Prog Urol. 1992 Feb;2(1):110-8.
One of the best known iatrogenic effects of anticancer treatments is the sterility of young patients with a good prognosis, hence the necessity to develop a protocol enabling us to preserve male reproductive function. This review of the literature summarises the various approaches investigated in order to obtain protection of spermatogenesis prior to radiotherapy and/or chemotherapy. Most of these pathways involve hormone therapy based on regulation of the hypothalamo-hypophyso-testicular axis. Animal models are generally used in these experiments. The various applications in man are described and discussed.
抗癌治疗最广为人知的医源性效应之一，是预后良好的年轻患者出现不育，因此有必要制定一套方案，使我们能够保留男性生殖功能。这篇文献综述总结了为在放疗和/或化疗前保护精子发生而研究的各种方法。这些途径大多涉及基于下丘脑-垂体-睾丸轴调节的激素治疗。这些实验一般使用动物模型。文中描述并讨论了在人体中的各种应用。
