Pang P K, Kaneko T, Benishin C G, Shan J, Lewanczuk R Z
Department of Physiology, University of Alberta, Edmonton.
J Endocrinol Invest. 1992;15(9 Suppl 6):79-85.
PHF, secreted by the PTG, induces hypertension by increasing vascular smooth muscle calcium uptake and thereby increasing intracellular calcium levels. PHF secretion is inhibited by dietary calcium and the effects of PHF are blocked by calcium channel antagonists. This explains the paradox whereby both calcium and calcium channel blockers may be effective antihypertensive agents. PHF may be secreted by a specific cell type in the parathyroid gland, numbers of which seem to correlate with PHF levels. Thus, the parathyroid gland does seem to play a role in some forms of hypertension, but this role is probably not due to its production of PTH, but may be related to the secretion of the new factor--PHF.
甲状旁腺生成的甲状旁腺高血压因子（PHF）通过增加血管平滑肌对钙的摄取，从而提高细胞内钙水平来诱发高血压。膳食钙可抑制PHF的分泌，钙通道拮抗剂可阻断PHF的作用。这就解释了为何钙和钙通道阻滞剂都可能是有效的抗高血压药物这一矛盾现象。PHF可能由甲状旁腺中的一种特定细胞类型分泌，其数量似乎与PHF水平相关。因此，甲状旁腺在某些形式的高血压中似乎确实发挥了作用，但这种作用可能并非由于其产生甲状旁腺激素（PTH），而可能与新因子——PHF的分泌有关。
