在大鼠海马切片CA1区，腺苷A1受体阻断剂对强直刺激通路中同突触抑制的选择性抑制作用。

Selective inhibition of homosynaptic depression in a tetanized pathway by an adenosine A1 blocker in the CA1 region of rat hippocampal slice.

作者信息

Sekino Y, Koyama I

机构信息

Department of Physiology, Tokyo Women's Medical College, Japan.

出版信息

Neurosci Lett. 1992 Dec 14;148(1-2):109-13. doi: 10.1016/0304-3940(92)90816-p.

DOI:10.1016/0304-3940(92)90816-p

PMID:1300482

Abstract

The involvement of adenosine A1 receptors in post-tetanic depression (PTD) of CA1, induced by 5 Hz, 20 s stimulation to the Schaffer collateral/commissural fibers was studied in the rat hippocampal slice. The tetanic stimulation induced post-tetanic depression (PTD) lasting for 5-10 min in the excitatory postsynaptic potentials (EPSP) and the population spike (PS) of the tetanized pathway (homosynaptic PTD), and of a non-tetanized pathway (heterosynaptic PTD). 8-Cyclopentyltheophylline (an adenosine A1 antagonist) blocked the induction of homosynaptic PTD, but not of heterosynaptic PTD. These results indicate that adenosine released during tetanic stimulation acts on the A1 receptor to induce the homosynaptic PTD.

摘要

在大鼠海马切片中，研究了腺苷A1受体在由5 Hz、20 s刺激海马Schaffer侧支/联合纤维诱导的CA1区强直后抑制（PTD）中的作用。强直刺激在强直化通路的兴奋性突触后电位（EPSP）和群体峰电位（PS）中诱导出持续5 - 10分钟的强直后抑制（PTD）（同突触PTD），以及在非强直化通路中诱导出强直后抑制（异突触PTD）。8-环戊基茶碱（一种腺苷A1拮抗剂）阻断了同突触PTD的诱导，但未阻断异突触PTD的诱导。这些结果表明，强直刺激期间释放的腺苷作用于A1受体以诱导同突触PTD。