Ettler K
Kozní klinika, Hradec Králové.
Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl. 1992;35(4):287-350.
The aim of the study was to elucidate the role of UV radiation in the etiology of malignant melanoma within the conditions of East Bohemia region. In selected patients with malignant melanoma, anamnestic data pertinent to the frequency of sun-bathing as well as a bulk of the occupational indoor exposures brought about the action of UV-light artificial sources have been withdrawn from past history. Constitutional features for suspected photosensitivity such as the fair skin complexion and skin phototype, were investigated. The object of assumption was also the site of anatomical localization (i. e. body site distribution) of primary malignant melanoma. In a selected group of patients, routine phototesting followed by the above-threshold skin phototests were carried out with the aim to assess the capacity of reparative processes essentially occurring in the irradiated skin. In the epidemiologically oriented part of study, presumable relationships between the year's maxima of sunlight radiation and the increases in the incidence of malignant melanoma were treated statistically. It followed from the results obtained that sunlight itself is not a decisive factor and cannot explain an increased incidence of malignant melanoma in East Bohemia region.
该研究的目的是阐明紫外线辐射在东波希米亚地区环境下对恶性黑色素瘤病因学的作用。在选定的恶性黑色素瘤患者中，已从既往病史中提取了与日光浴频率以及大量由紫外线人工光源导致的职业室内暴露相关的既往史数据。对疑似光敏性的体质特征，如白皙的皮肤肤色和皮肤光型进行了调查。假设的对象还包括原发性恶性黑色素瘤的解剖定位部位（即身体部位分布）。在选定的一组患者中，进行了常规光测试，随后进行了阈上皮肤光测试，目的是评估主要在受照射皮肤中发生的修复过程的能力。在该研究以流行病学为导向的部分，对阳光辐射的年度最大值与恶性黑色素瘤发病率增加之间的可能关系进行了统计学处理。从获得的结果可以看出，阳光本身不是一个决定性因素，无法解释东波希米亚地区恶性黑色素瘤发病率的增加。
