Spryshkova R A, Grigor'eva E Iu, Brattsev V A, Sevast'ianov A I, Naĭdenov M G
Vopr Onkol. 1992;38(3):327-34.
C57BL/6 male mice bearing subcutaneously transplanted melanoma B-16 were used to study the applicability of 5-iodine-2'-deoxyuridine labeled with iodine 125 and 131 radionuclides to assess individual tumor response to radiation. The experiments using intact animals and those locally irradiated in the dose of 10 Gy revealed a correlation between excretion of the above-mentioned radioactive labels from tumor area and tumor growth rate for each mouse (correlation coefficient r = 0.93-0.97). 5-Iodine-2'-deoxyuridine excretion rate measurement can be used in express (24-48 hr) tests of individual tumor response to radiation.
使用皮下移植黑色素瘤B-16的C57BL/6雄性小鼠来研究用碘125和131放射性核素标记的5-碘-2'-脱氧尿苷评估个体肿瘤对辐射反应的适用性。对完整动物和局部照射剂量为10 Gy的动物进行的实验表明，每只小鼠肿瘤区域上述放射性标记物的排泄与肿瘤生长速率之间存在相关性（相关系数r = 0.93 - 0.97）。5-碘-2'-脱氧尿苷排泄率测量可用于个体肿瘤对辐射反应的快速（24 - 48小时）检测。
