Anisimov V N, Miretskiĭ G I, Morozov V G, Pavel'eva I A, Khavinson V Kh
Vopr Onkol. 1992;38(4):451-8.
Five month-old female rats were given a mixture of Sr-90 and Cs-137 in drinking water in the dose of 0.1 and 0.2 microCi/day per animal over 12 months. Some animals received 12 monthly courses of a synthetic immunomodulating dipeptide--thymogen in the dose of 5 micrograms/animal for 5 consecutive days. Radionuclide-treated rats showed higher occurrence of tumors on the whole and of breast adenocarcinoma, in particular. Thymogen was shown to inhibit Sr-90- and Cs-137-induced radiation carcinogenesis, namely, a decrease in the total tumor and cancer occurrence was observed. The animals receiving thymogen alone showed longer life span, slower rate of aging and lower overall tumor and cancer occurrence. In this study, the ability of a synthetic peptide immunomodulator--thymogen to inhibit spontaneous and radionuclide-induced carcinogenesis in female rats was first established.
给5月龄雌性大鼠饮用含Sr-90和Cs-137的混合水，剂量为每只动物每天0.1和0.2微居里，持续12个月。一些动物连续5天接受每月12个疗程的合成免疫调节二肽——胸腺生成素，剂量为每只动物5微克。接受放射性核素处理的大鼠总体上肿瘤发生率更高，尤其是乳腺腺癌。胸腺生成素被证明可抑制Sr-90和Cs-137诱导的辐射致癌作用，即观察到肿瘤和癌症总发生率降低。单独接受胸腺生成素的动物寿命更长，衰老速度更慢，总体肿瘤和癌症发生率更低。在本研究中，首次证实了合成肽免疫调节剂——胸腺生成素抑制雌性大鼠自发性和放射性核素诱导致癌作用的能力。
