Bory M
Service de Cardiologie A, Hôpital de la Timone, Marseille.
Ann Cardiol Angeiol (Paris). 1992 Dec;41(10):595-7.
Hospital mortality due to myocardial infarction has decreased markedly since the 1970's. Intravenous thrombolysis is certainly one of the reasons for this decrease but its precise role cannot be defined. In practice, major therapeutic trials enable definition of the broad lines. It is nevertheless essential to combine our personal experience with their analysis. It is not yet possible at present to say which is the best thrombolytic. Use of the association streptokinase-rtPA has the advantages of both agents and the same risks at a lower cost than that of rtPA alone.
自20世纪70年代以来,因心肌梗死导致的医院死亡率显著下降。静脉溶栓疗法无疑是死亡率下降的原因之一,但其确切作用尚无法明确界定。实际上,大型治疗试验能够确定大致的治疗方案。然而,将我们的个人经验与试验分析相结合至关重要。目前尚无法确定哪种溶栓剂是最佳的。联合使用链激酶和重组组织型纤溶酶原激活剂(rtPA)具有两种药物的优点,且风险相同,但成本低于单独使用rtPA。