Manski W
Arch Ophtalmol Rev Gen Ophtalmol. 1975 Feb;35(2):167-80.
Two types of corneal cell membrane receptors are described, one occurs on the surface of only regenerating or cultured cells, that is, actively metabolizing and/or proliferating ones. The other type of corneal membrane receptors occurs on the cell surface independent of the metabolic state, e.g. on excised resting cells. In contrast to the restricted ontogenic specificity of the metabolically dependent corneal cell membrane antigens, the metabolically independent cell surface antigens were found to be universally distributed across ontogenic or species barriers. Such metabolically independent corneal cell surface antigens include Forssman or blood group antigens. The immuno-cytotoxic reaction of corneal cells involving the metabolically independent cell surface antigens was enhanced by complement, whereas a similar immunocytotoxic reaction involving the metabolically dependent antigens was not.
本文描述了两种角膜细胞膜受体，一种仅出现在正在再生或培养的细胞表面，即处于活跃代谢和/或增殖状态的细胞。另一种角膜膜受体出现在细胞表面，与代谢状态无关，例如在切除的静止细胞上。与代谢依赖性角膜细胞膜抗原有限的个体发生特异性相反，发现代谢非依赖性细胞表面抗原在个体发生或物种屏障中普遍分布。这种代谢非依赖性角膜细胞表面抗原包括福斯曼抗原或血型抗原。涉及代谢非依赖性细胞表面抗原的角膜细胞免疫细胞毒性反应可被补体增强，而涉及代谢依赖性抗原的类似免疫细胞毒性反应则不然。
