Lobaccaro J M, Sultan C
Unité de Biochimie Endocrinienne du Développement et de la Reproduction, Hôpital Lapeyronie, Montpellier, France.
C R Seances Soc Biol Fil. 1992;186(4):314-31.
Analysis of the sexual determination and differentiation factors has progressed by the important findings made in biochemistry (hormonal assays, determination of the receptor concentration), in cellular and molecular endocrinology (mechanism of the hormonal action) and in genetics (identification, isolation and cloning of the genes implied in the sexual determination and differentiation pathways). We first describe the basis of sexual determination and differentiation, and then we analyze the different roles of SRY gene, encoding for the testis determining factor, androgen receptor gene, 5 alpha-reductase gene and anti-Müllerian hormone gene.
通过生物化学（激素测定、受体浓度测定）、细胞与分子内分泌学（激素作用机制）以及遗传学（鉴定、分离和克隆性决定和分化途径中涉及的基因）方面取得的重要发现，性决定和分化因子的分析取得了进展。我们首先描述性决定和分化的基础，然后分析编码睾丸决定因子的SRY基因、雄激素受体基因、5α-还原酶基因和抗苗勒管激素基因的不同作用。
