Takeda E, Yamane H, Okiyama R, Shimizu N
Department of Otolaryngology, Teikyo University School of Medicine, Ichihara Hospital.
Rinsho Shinkeigaku. 1992 Nov;32(11):1245-9.
We report a sporadic case of periodic ataxia characterized by recurrent attacks of vertigo and ataxia. A 62-year-old male was known to have nystagmus at the age of 18. He has had recurrent episodes of vertigo and ataxia since the age of 48. During an attack remarkable downbeat nystagmus, limb ataxia predominant in the lower extremities and ataxic gait were present. MRI demonstrated an atrophy of the anterosuperior region of the cerebellar vermis. Vertical nystagmus, dysesthesia of gloves and stocking type and deep sensory disorder persisted during interictal intervals. There is no finding which supports this case to be vascular disorder, congenital anomaly, tumor, infection or demyelinating disease. We thought this case to be periodic ataxia and to belong to vestibulocerebellar ataxia reported by Farmer and his colleagues.
我们报告一例散发性周期性共济失调病例，其特征为眩晕和共济失调反复发作。一名62岁男性在18岁时被发现有眼球震颤。自48岁起，他就反复出现眩晕和共济失调发作。发作期间出现明显的下跳性眼球震颤、以下肢为主的肢体共济失调和共济失调步态。MRI显示小脑蚓部前上区域萎缩。发作间期垂直性眼球震颤、手套和袜套样感觉异常及深感觉障碍持续存在。没有证据支持该病例为血管性疾病、先天性异常、肿瘤、感染或脱髓鞘疾病。我们认为该病例为周期性共济失调，属于Farmer及其同事报道的前庭小脑性共济失调。
