Lukić V, Husek A, Gasić O, Walterova D, Simanek V
Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Yugoslavia.
Eur J Drug Metab Pharmacokinet. 1992 Oct-Dec;17(4):243-6. doi: 10.1007/BF03190154.
The major pathway of metabolic transformation of N-deacetyl-N-formylcolchicine is the oxidative cytochrome P450 dependent O-demethylation of substituents in the aromatic ring A and tropolone ring C. It was found that O-demethylation (both, in vitro and in vivo) takes place predominantly in the aromatic ring, especially at position 2.
N-脱乙酰基-N-甲酰基秋水仙碱代谢转化的主要途径是芳香环A和托酚酮环C中取代基的氧化细胞色素P450依赖性O-去甲基化。研究发现，O-去甲基化（在体外和体内）主要发生在芳香环中，尤其是在2位。
