坏死性血管炎：一种产生循环免疫复合物的炎性皮肤病变。

Necrotizing vasculitis: a circulating immune complex producing inflammatory skin lesions.

作者信息

Jones J V, Cumming R H, Asplin C M, Harman R R, Tribe C R

出版信息

Br J Dermatol. 1976 Feb;94(2):123-30. doi: 10.1111/j.1365-2133.1976.tb04360.x.

DOI:10.1111/j.1365-2133.1976.tb04360.x

Abstract

A patient with acute necrotizing vasculitis is described in whom tests for circulating immune complexes were negative. The patient's serum injected intradermally produced lesions which closely resembled those occurring spontaneously. When the serum was fractionated, the skin-reactive fraction was found to be associated with IgG, but was of a higher molecular weight than normal IgG. Immunofluorescent studies showed that lesions induced by this active fraction contained IgG and complement in the epidermal basement membrane zone and within the small dermal vessels. We conclude that an immune complex of relatively low molecular weight is present in the active fractions, and capable of initiating the lesions of acute necrotizing vasculitis.

摘要

本文描述了一名急性坏死性血管炎患者，其循环免疫复合物检测呈阴性。将该患者的血清皮内注射后产生的皮损与自发出现的皮损极为相似。当对血清进行分级分离时，发现具有皮肤反应性的部分与IgG相关，但分子量高于正常IgG。免疫荧光研究表明，由该活性部分诱导产生的皮损在表皮基底膜区和真皮小血管内含有IgG和补体。我们得出结论，活性部分中存在相对低分子量的免疫复合物，且能够引发急性坏死性血管炎的皮损。