[克班宁的抗心律失常作用]
[Antiarrhythmic effects of crebanine].
作者信息
Yu Z P, Mu Y S, Zhao Z X, Wang F C
机构信息
Department of Traditional Chinese Pharmacy, Yunnan College of TCM, Kunming.
出版信息
Zhongguo Zhong Yao Za Zhi. 1992 Nov;17(11):685-7, 704.
PMID:1301759
Abstract
Crebanine (Cre) iv 5 mg/kg could convert BaCl2-induced arrhythmia into sinus rhythm in rats, and could significantly increase the tolerant dose of aconitine to produce ventricular fibrillation (VF) and cardiac arrest (CA) in rats. The drug could also decrease the incidence of VF and CA by CaCl2 in rats and by chloroform in mice, but had no protective effects on ouabain-induced arrhythmias in guinea pigs.
摘要
克班宁（Cre）静脉注射5毫克/千克可使大鼠由氯化钡诱导的心律失常恢复为窦性心律，并能显著提高大鼠对乌头碱致室颤（VF）和心脏骤停（CA）的耐受剂量。该药物还可降低氯化钙所致大鼠以及氯仿所致小鼠的VF和CA发生率，但对哇巴因诱导的豚鼠心律失常无保护作用。
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