Tanahashi T, Mochizuki K, Torisaki M, Yamashita Y, Komatsu M, Higashide T, Ogata M
Department of Ophthalmology, Kanazawa University School of Medicine, Japan.
Lens Eye Toxic Res. 1992;9(3-4):493-503.
The effect of an intravitreal injection of norfloxacin on the retina was evaluated by in-vivo electroretinogram (ERG) and histological examination in pigmented rabbits. The intraocular pharmacokinetics after an intravitreal injection of norfloxacin were also investigated. An intravitreal injection of 50 micrograms norfloxacin produced no significant change in the ERG. An injection of 500 micrograms norfloxacin decreased the amplitude of the oscillatory potentials, and delayed their peak latencies 3 hours after the injection, but these changes recovered within 7 days. A marked suppression of the c-wave was noted in one pigmented rabbit. Neither 50 micrograms nor 500 micrograms norfloxacin caused any apparent changes in the visual evoked potential and in the retinal histology 7 days after the injection. The intraocular pharmacokinetic study showed that the concentration of norfloxacin in the choroid-retina was almost the same level as that in the vitreous body 3 hours after the injection. However, the former was higher than the latter 7 days after the injection, suggesting the persistency of norfloxacin in the choroid-retina. An intravitreal injection of 50 micrograms norfloxacin could be used without retinal toxicity. A high dose-intravitreal use of norfloxacin needs careful attention with respects to its persistency in the pigmented ocular tissues.
通过对有色家兔进行活体视网膜电图（ERG）和组织学检查，评估了玻璃体内注射诺氟沙星对视网膜的影响。还研究了玻璃体内注射诺氟沙星后的眼内药代动力学。玻璃体内注射50微克诺氟沙星后，ERG无明显变化。注射500微克诺氟沙星会降低振荡电位的幅度，并在注射后3小时延迟其峰值潜伏期，但这些变化在7天内恢复。在一只有色家兔中观察到c波明显抑制。注射后7天，50微克和500微克诺氟沙星均未引起视觉诱发电位和视网膜组织学的任何明显变化。眼内药代动力学研究表明，注射后3小时，脉络膜视网膜中诺氟沙星的浓度与玻璃体中的浓度几乎相同。然而，注射后7天，前者高于后者，这表明诺氟沙星在脉络膜视网膜中具有持久性。玻璃体内注射50微克诺氟沙星可无视网膜毒性使用。高剂量玻璃体内使用诺氟沙星时，需要注意其在有色眼组织中的持久性。
