Xue C R, Zhu L W, Wu X Z
Affiliated Hospital of Tianjin Medical College.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 Nov;12(11):652-5, 643.
52 Patients with Blood Stasis Syndrome (BSS) in abdominal surgical diseases were divided into 3 types according to their symptoms, signs and natures of diseases. Peripheral blood T lymphocyte subsets of these BSS patients and 12 healthy persons were studied with Flow Cytometry and monoclonal antibodies. The immunoglobulins and complements of these cases were also studied. There were no difference in T cell subsets, immunoglobulins and complements between Qizhi-BSS group and normal control. The Shire-BSS group showed that CD8 cell, IgG, IgM, and C1, C3c were increased. These results showed that the immune response increased in this type of BSS patients. In the Qixu-BSS group, the CD3 was nearly normal, and the CD4+, CD4+/CD8+ ratio, and CD16+ were statistically decreased. However, the CD8+ cells markedly increased, the IgG, IgM and IgD were also lowered significantly in this type. The marked morphologic abnormal changes in ultrastructures of T lymphocyte were found in 6 patients with Qixu-BSS group. These results showed that the Qixu type of Blood Stasis Syndrome patients were in the immuno-suppressive status.
将52例腹部外科疾病血瘀证患者,按症状、体征及疾病性质分为3型。采用流式细胞仪及单克隆抗体技术,对这些血瘀证患者及12例健康人的外周血T淋巴细胞亚群进行研究,同时对这些病例的免疫球蛋白及补体进行检测。气滞血瘀证组与正常对照组在T细胞亚群、免疫球蛋白及补体方面无差异。湿热血瘀证组显示CD8细胞、IgG、IgM及C1、C3c升高。这些结果表明,此类血瘀证患者免疫反应增强。气虚血瘀证组中,CD3基本正常,CD4 +、CD4 +/CD8 +比值及CD16 +在统计学上降低。然而,该型CD8 +细胞明显增多,IgG、IgM及IgD也显著降低。气虚血瘀证组6例患者T淋巴细胞超微结构出现明显形态学异常改变。这些结果表明,气虚型血瘀证患者处于免疫抑制状态。