Zhonghua Yi Xue Za Zhi. 2003 Jun 25;83(12):1014-7.
To study the immunological changes in patients suffered from severe acute respiratory syndrome (SARS).
T-lymphocyte subsets of peripheral blood from 124 patients with different phases of SARS were measured by flow cytometry. Immunoglobulins were examined simultaneously. Blood specimens from 51 patients with AIDS and 57 normal persons were collected as controls and subjected to the same measurements.
The levels of CD3(+), CD4(+) and CD8(+) T-lymphocytes in SARS group [(589 +/- 435) x 10(6)/L, (316 +/- 267) x 10(6)/L and (215 +/- 165) x 10(6)/L, respectively] were significantly lower than those of the normal group (P < 0.01). When compared the SARS group with AIDS group, we found the level of CD4(+) T-lymphocyte in the former was higher (P < 0.01), while the CD3(+) and CD8(+) T-lymphocytes were lower (P < 0.01). There were 54 (44%) patients in SARS group and 39 (76%) patients in AIDS group showed low levels of CD4(+) T-lymphocyte (< 200 x 10(6)/L). The count of T-lymphocyte subsets of SARS group decreased to the lowest level during the 10(th) and 12(th) day after the onset of symptoms. Both serum IgG and IgE in SARS group [(15.1 +/- 8.5) g/L and (0.6 +/- 0.9) g/L, respectively] were higher than those of the normal group.
The levels of CD3(+), CD4(+) and CD8(+) T-lymphocyte subsets in peripheral blood of SARS patients decrease significantly and go down to the lowest point at days 10 approximately 12 after onset of the disease.
研究严重急性呼吸综合征（SARS）患者的免疫变化。
采用流式细胞术检测124例处于不同阶段的SARS患者外周血T淋巴细胞亚群，并同时检测免疫球蛋白。收集51例艾滋病患者和57例正常人的血液标本作为对照，进行同样的检测。
SARS组CD3(+)、CD4(+)和CD8(+) T淋巴细胞水平分别为(589±435)×10⁶/L、(316±267)×10⁶/L和(215±165)×10⁶/L，显著低于正常组（P<0.01）。SARS组与艾滋病组比较，前者CD4(+) T淋巴细胞水平较高（P<0.01），而CD3(+)和CD8(+) T淋巴细胞水平较低（P<0.01）。SARS组有54例（44%）患者和艾滋病组有39例（76%）患者CD4(+) T淋巴细胞水平低（<200×10⁶/L）。SARS组T淋巴细胞亚群计数在症状出现后第10天和第12天降至最低水平。SARS组血清IgG和IgE水平分别为(15.1±8.5)g/L和(0.6±0.9)g/L，均高于正常组。
SARS患者外周血CD3(+)、CD4(+)和CD8(+) T淋巴细胞亚群水平显著降低，在发病后第10至12天降至最低点。
