Graef A, Romero M A, González M, Pierzo J A, Sosa R, Altamirano P
Departamento de Medicina Nuclear, Hospital de Especialidades, Instituto Mexicano del Seguro Social.
Gac Med Mex. 1992 Mar-Apr;128(2):91-5.
The age of monoclonal antibodies arose with the papers by Köhler and Milstein in 1975. By means of a fusion between a neoplastic cell with one which produced a specific antibody they obtained a hybrid or clonal cell. Five years later, Nadler et al issued the first report of a patient with lymphoma treated with monoclonal antibodies. After the first announcement, diverse research centers have reported the clinical results obtained in various neoplasias treated with radioactive monoclonal antibodies directed against antigens associated with neoplasias, as well as non-specific tumoral antigens, including lymphomas, melanomas and cancers of the colon, ovary and breast.
单克隆抗体时代始于1975年科勒和米尔斯坦发表的论文。通过将一个肿瘤细胞与一个产生特异性抗体的细胞进行融合，他们获得了一个杂交或克隆细胞。五年后，纳德勒等人发表了首例用单克隆抗体治疗淋巴瘤患者的报告。首次宣布后，多个研究中心报告了在用针对与肿瘤相关抗原以及非特异性肿瘤抗原（包括淋巴瘤、黑色素瘤以及结肠癌、卵巢癌和乳腺癌）的放射性单克隆抗体治疗各种肿瘤时所取得的临床结果。
