[抗疟药伯氨喹的体外肝微粒体代谢]
[In vitro liver microsomal metabolism of antimalarial primaquine].
作者信息
Ni Y C, Wang M J, Xu Y Q
机构信息
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai.
出版信息
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1992;10(4):275-8.
The profile of the major metabolites of primaquine produced by in vitro liver microsomal metabolism was investigated with silica gel thin-layer and high performance liquid chromatography (HPLC) analysis. The results indicated that the liver microsomal metabolism could simultaneously produce both 5-OH PQ (quinoline ring oxidation product) and CPQ (side-chain oxidative deamination product). However, the quantitative comparative study of microsomal metabolism showed that the production of 5-OH PQ was far much higher than that of CPQ.
通过硅胶薄层色谱和高效液相色谱（HPLC）分析，研究了伯氨喹经体外肝微粒体代谢产生的主要代谢物的概况。结果表明，肝微粒体代谢可同时产生5-羟基伯氨喹（喹啉环氧化产物）和羧基伯氨喹（侧链氧化脱氨产物）。然而，微粒体代谢的定量比较研究表明，5-羟基伯氨喹的生成量远高于羧基伯氨喹。
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