Xia Z H, Su Y L, Yao S Y, Shen B R, Wen L Y, Song C C, Wu Z K, Zou Y C, Meng J C, Yang H L
Institute of Parasitic Diseases, Zhejiang Academy of Medical Sciences, Hangzhou.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1992;10(4):279-82.
A total of 166 cases were divided into 3 groups: group A comprised 55, group B 54 and group C 57 cases. Group A received ivermectin 0.1 mg/kg orally at a single dose, the cure rates were 100%, 3.8% and 50% for ascaris, hookworm and trichuris, infections respectively: group B received ivermectin 0.2 mg/kg orally at a single dose, the corresponding cure rates were 95.5%, 11.8% and 76.5% respectively; group C received pyrantel pamoate 10 mg/kg orally at a single dose, the corresponding cure rates were 95.5%, 29.6% and 31.6% respectively. Although the cure rates were very low for hookworm infection in both group A and B, however, a number of adult worms of Ancylostoma duodenale and Necator americanus were expelled aster medication; It indicates that ivermectin has some effects on these two species of human hookworm. Side effects were mild and transient in all groups.
总共166例患者被分为3组：A组55例，B组54例，C组57例。A组患者口服单剂量伊维菌素，剂量为0.1mg/kg，蛔虫、钩虫和鞭虫感染的治愈率分别为100%、3.8%和50%；B组患者口服单剂量伊维菌素，剂量为0.2mg/kg，相应的治愈率分别为95.5%、11.8%和76.5%；C组患者口服单剂量噻嘧啶，剂量为10mg/kg，相应的治愈率分别为95.5%、29.6%和31.6%。虽然A组和B组钩虫感染的治愈率都很低，但是，用药后排出了一些十二指肠钩虫和美洲板口线虫成虫；这表明伊维菌素对这两种人体钩虫有一定作用。所有组的副作用均轻微且短暂。
